The use of Erythromycin for infant acid reflux. Tolerance and what happens in a placebo test will SURPRISE you! Read this important information about why it isn't the best treatment option for your baby's reflux.

Occasionally we will get a parent in our Facebook support group requesting information about the efficacy and effects of this drug, which has been prescribed for the use in treating infant GERD.  The theory behind it's use is it stimulates the stomach to empty. It stimulates a motility receptor (called Motilin).

Erythromycin in liquid form

Background: Feeding intolerance is a common condition that affects preterm infants. Erythromycin is a prokinetic agent used to treat feeding intolerance, but its efficacy remains inconclusive.

Objective: To evaluate the effectiveness of oral erythromycin to enhance feeding tolerance in preterm infants.

Methods: This prospective, randomized controlled trial in preterm infants was conducted at Sanglah Hospital, Denpasar, Bali, from June 2015 to January 2016. Eligible infants were randomized to receive either 12.5 mg/kg/dose oral erythromycin or a placebo, every 8 hours. The primary outcome was the time to establish full enteral feeding. The secondary outcomes were body weight at full enteral feeding and length of hospital stay.

Results: Of 62 initial subjects, 3 infants dropped out of the study. Thirty infants were given erythromycin and 29 infants were given placebo. The baseline characteristics of the two groups were similar, with mean of gestational ages of 31.4 (SD 1.7) weeks in the erythromycin group and 32.4 (SD 2.2) weeks in the placebo group. The median times to reach full enteral feeding did not significantly differ between the two groups, with 10 (SD 5.3) days in the erythromycin group vs. 8 (SD 6.5) days in the placebo group (P=0.345). Also, median body weights at full enteral feeding and lengths of hospital stay were not significantly different between the two groups.

Conclusion: Erythromycin of 12.5 mg/kg/dose every 8 hours as prophylactic treatment does not significantly enhance feeding tolerance in preterm infants. Median body weights at full enteral feeding and length of hospital stay are not significantly different between the erythromycin and placebo groups.


The above article also states that there is no difference between Erythromycin and Placebo.

Erythromycin and Tolerance Article 2

Here is another recent review of tachyphylaxis (tolerance).  The abilities of non-peptide motilin receptor agonists (such as erythromycin) to activate the recombinant motilin receptor and cause muscle contraction in vitro are also each subject to rapid desensitization (tolerance).


We hope these resources make sense to you and if you have any questions you can reach out to us with questions.

And you can always work with our on staff doctor that has been specializing in infant reflux EXCLUSIVELY for the past 25 years. You can read the reviews here.

Home Page