MSPI and FPIES are both food related allergies generally known to be triggered by proteins. This page is to help understand how these conditions relate to acid reflux in infants.

Infant Acid Reflux Solutions uses evidence based medicine to provide information to help families with babies suffering from infant acid reflux. Here are some key resources for you to review carefully with your medical team.

MSPI stands for Milk and Soy - Protein Intolerance. The evidence based medicine that supports the diagnosis of this condition that effects about 85,000 infants a year, is that it is triggered by proteins found in milk and soy and is one of the most common food-related intolerance among infants.
Source: WIKIPEDIA Milk soy protein intolerance page

FPIES stands for Food Protein-Induced Enterocolitis syndrome and is a severe systemic response to food protein that typically occurs in 1-4 hours after the ingestion of the trigger food. It typically develops in the first few years of life.
WIKIPEDIA Food protein-induced enterocolitis syndrome page.
UpToDate Food Protein Induced Enterocolitis Syndrome page. is a site that physicians use to remain up to date and the site refreshes it’s information (based on evidence) every month.

According to these sources this quote: “Although cow's milk and soy protein are the most common triggers, food protein-induced enterocolitis can be triggered by other proteins, such as rice or oat, particularly in infants who have had a previous reaction to cow's milk or soy.
FPIES may be induced by solid food, including grains (rice, oats, barley, corn), meat and poultry (beef, chicken, turkey), eggs (egg white), vegetables and fruit (white potato, sweet potato, squash, string beans, mushroom, banana, apple, tomato), legumes (peanut, green peas, lentils), seafood (fish, crustaceans, mollusks), and the probiotic Saccharomyces boulardii (bacteria contains protein)” Indicates any food that has traces of “protein” could cause an FPIES reaction.

Please note that all the foods indicated in that list have traces of protein.

Although there can be many different types of food intolerance's, most will create symptoms such as acid reflux. It's important to know that if your child has MSPI or FPIES (protein related allergies) there can be other allergies of food intolerance's present in addition to MSPI or FPIES.

Nobody wants to cause pain or injury to a baby, including us and the families that are trying to provide information to other families. So, please acquire as much information as possible before making a treatment choice.

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