MSPI and FPIES are both food related allergies generally known to be triggered by proteins. This page is to help you understand how these conditions relate to infant GERD.

Infant Acid Reflux Solutions uses evidence based medicine (science) to provide information and treatments to families with suffering babies.

MSPI stands for Milk and Soy - Protein Intolerance. About 85,000 infants a year suffer and is triggered by proteins found in milk and soy. It's one of the most common food-related intolerance among infants.

CMPI is another acronym for Cow's Milk Protein Intolerance.

FPIES stands for Food Protein-Induced Enterocolitis syndrome and is a severe systemic response to food protein that typically occurs in 1-4 hours after the ingestion of the trigger food. It typically develops in the first few years of life.

All three condtions require the presence of protein as the cause of the condition. It's true that many ingredients have hidden traces of protein and you should consult your nutritional coach about products that may cause a reaction in your child.

UpToDate Food Protein Induced Enterocolitis Syndrome page. is a site that physicians use to remain up to date and the site refreshes it’s information (based on evidence) every month.

According to these viable sources: “Although cow's milk and soy protein are the most common triggers, food protein-induced enterocolitis can be triggered by other proteins, such as rice or oat, particularly in infants who have had a previous reaction to cow's milk or soy.
FPIES may be induced by solid food, including grains (rice, oats, barley, corn), meat and poultry (beef, chicken, turkey), eggs (egg white), vegetables and fruit (white potato, sweet potato, squash, string beans, mushroom, banana, apple, tomato), legumes (peanut, green peas, lentils), seafood (fish, crustaceans, mollusks), and the probiotic Saccharomyces boulardii (bacteria contains protein) Indicates any food that has traces of protein could cause an FPIES reaction.

Although there can be many different types of food intolerance's, most will create symptoms such as acid reflux. It's important to know that if your child has MSPI or FPIES (protein related allergies) there can be other allergies of food intolerance's present in addition to MSPI or FPIES.