H2 blockers and your baby's acid reflux. How they help and why they seem to stop working.
Although the use of an H2 Blocker is GREAT for sporadic or mild reflux, they may not be the best choice for moderate, severe and/or constant reflux symptoms because the human body will build a tolerance to H2 blockers. You will likely notice depleting effectiveness in about 7 to 14 days. This is called tachyphylaxis (or tolerance). Here's information about that study.
So even if the H2 blocker provides some relief initially, your baby
might rapidly develop tolerance and becomes it ineffective. It's important to know that increasing
the dose of the blocker will not help. Also, histamine 2 blockers
contain alcohol which is a mucosal irritant and may cause frequent
They work by blocking the messengers that tell the stomach to begin production of acid. These signals are delivered by the messenger hormones called histamine (type 2). Histamine communicates with the cell by attaching to contact points located on the cell surface called receptors. H2 Blockers work by occupying the receptors so that histamine cannot bind and communicate to the acid producing cell and therefore it can not produce acid.