Proton Pump Inhibitors
Proton Pump inhibitors can play an integral part in treating you baby's infant acid reflux. It is one of many treatment options available to you.
This information will also assist you in making the best choice if you decide to purchase TummyCare Max®.
The clinical description
of a PPI drug is a chemical compound (the technical name for medicine) that irreversibly inactivates the
pumps that produce stomach acid while the medication is in its effective
stage (the effective stage refers to the duration when the medicine starts and stops working).
accurately describe a proton pump we need to describe the parietal
cells that are located in the stomach. The function of the parietal
cells are to secrete acid into the stomach to assist in breaking down
what has been ingested (eaten). Proton pumps are part of this cell's
membrane and that is the portion of the cell that pumps out the acid
that the parietal cell secretes into the stomach.
within the parietal cell's surface where acid is secreting. PPI's reach
the location of the parietal cell secretion point through the blood
stream. The PPIs react to the cell in a way that inactivates, both the
pumps from secreting acid and in turn inactivates the parietal cells
from producing acid.
The question is how do PPIs relate to
infant acid reflux and are they safe to use and an infant acid reflux
treatment? The answer is yes. PPI's are the safest, most effective
medications available for treating acid reflux in both infants and
children and the following have been approved by the FDA for pediatric
- Esomeprazole, found in Nexium®
- Omeprazole, found in Zegerid®, Prilosec® and generic forms
- Lansoprazole, found in Prevacid®
- Pantoprazole, found in Protonix®
more in-depth information read the PPI Dosing Information Page This is very helpful in
understanding the Marci-kids dosing used by the
University of Missouri and Marcella Bothwell ENT and Jeffrey Phillips Pharm D. (Dr. P) in effectively treating
infant acid reflux.
Note: The doses recommended in the PPI
information page and on the PPI dosing chart are not recommended by any
proton pump inhibitor manufacturer or distribution company. These
recommendations are representative of typical dosing used at Marci-kids
website and have been proven to be effective in most cases.
We would like to point out that it is important that you review and discuss all infant acid reflux treatment intentions with your doctor before making your decision. We encourage you to refer anybody in your care provider team to refer to this website, this page and for your convenience we have printable version in PDF form
for you to bring to your next doctors appointment.
It is important that you acquire as much information about your options before you and your medical care team make a decision about whether TummyCare Max®
is a good fit for you.
TummyCare Max® is intended to be used under the supervision of your doctor and all treatment options should be discussed with your medical team prior to use.
Proton Pump Inhibitor Categories
There are a number of proton pump inhibitor products on the market today.
- Prescription (Rx)
- Over the counter (OTC)
Then they are further categorize as:
- Delayed Release PPI: In this form, the PPI is contained in an enteric-coated beads, granules or tablet. The enteric-coating is resistant to stomach acid and allows the medication to be ingested and make it through the acid of the stomach to the small intestine where the PPI is absorbed into the blood stream where it inactivates the production of acid from the parietal cells. So basically if the medication hits the stomach acid in an unprotected form, it would be destroyed by the stomach acid and becomes useless as a treatment. That is the benefit of having the enteric coating, or some sort of protection via capsule, on the drug itself. The downside is, protecting the medication with a coating of some sort also delays the effect until it reaches the small intestine. That process, from the time your baby ingests the proton pump inhibitor, until it takes effect in the small intestine can take up to two hours
- Immediate Release PPI: This form of PPI is suspended in an alkaline buffer that neutralizes the stomach acid and it replaces the need of having the enteric coating on the PPI. Zegerid® is currently the only immediate release PPI product that is available in both Rx and OTC and is FDA approved. (Because Zegerid is an immediate release PPI, it contains too much
sodium bicarbonate, which is very harsh on a babies belly, it can not be
used with TummyCare Max®)
PPI's come in both OTC and Rx forms. No matter what form of PPI product you are using, whether
it's OTC or RX, TummyCare Max® can be used. Some examples are lansoprazole and ompeprazole. TummyCare Max® provides treatment for your baby's acid
reflux without timing around meals or having to wait up to two hours for
your child to get relief from painful acid reflux and makes any PPI into an immediate release product so you don't have to time around feedings. But that is just one of the many benefits of using TummyCare Max®.
Proton Pump Inhibitor Use Feedback
- Prilosec® / Omperazole: Omeprazole, as mentioned previously, is the the generic version of Prilosec. Omeprazole has had the best feed back from the Moms that have used TummyCare Max®. It seems to have the least amount of side effects.
- Prevacid® / Lansoprazole: It is the second highest choice by the Moms who use TummyCare Max®. However, we do know that Prevacid® is not a stable and can loose it's efficacy in about a week to ten days. This is why we provided half packet mixing instructions on our mixing instructions page. The other issue that seems to present itself is appetite suppression and less sleeping. Although there are some Moms that swear by Prevacid®.
- Nexium® / Esomeprazole: Although Nexium® can propose the most difficulty in mixing because you need to seperate the beads, it has shown to be very successful and Moms do like using it to treat their babies infant acid reflux. The biggest complaint we get with using Nexium® is that it's very bitter. We have suggested to dip your finger in TummyCare Max® powder (mixed alone) and let
your baby lick that before giving the syringe with Nexium and TCMax!
- Protonix® / Pantoprazole: We have not had much feedback or interaction nor have we had any Moms say they've used this PPI. Nor do we have any mixing instructions available for this option of proton pump inhibitor.
We'd like to mention that we do not support nor discourage the use of any of the PPI options above. The variables are present and it really is your choice which option is best to treat your baby's reflux.
This is a great time to pop over to that Acid & pH page and read about how acid and pH levels work, with interactive images that actually show you the process of digestion in a baby.
A proton pump inhibitor can be highly
effective in controlling acid production. Additionally they have proven
to be very safe and all of the PPIs on the market have very few, if any,
side effects. Be sure to read about the contraindications (WHAT NOT TO DO OR USE WHEN USING A PROTON PUMP INHIBITOR) of using PPI's.
What to avoid giving or doing when administering PPI Drugs in infants with acid reflux.
PPI DOSING INFORMATION:
To assist you in understanding the Proton Pump Dosing regimen as suggested with our products.